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Another study (98) has shown that triptolide inhibits the proliferation of FLSs and the expression of inflammatory cytokines (IL-1, IL-6, and VEGF) induced by IL-6/sIL-6R complex by inhibiting the JAK2/STAT3 signaling pathway

44 Thus, apart from tumor thickness greater than 5 mm and the presence of lymphovascular invasion, many of the histologic prognostic parameters of cutaneous melanoma (i.e., Breslows classification and Clarks level of invasion) do not apply to oral melanoma

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