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As expected, Mat1a ASO treatment increased FGF21 in serum of HFD-fed AlbCre mice while it did not affect FGF21 levels in HFD-fed AlbCre- Fgf21 mice, in which serum FGF21 levels were hardly detectable (Fig

Abbreviations AGEs: Advanced glycation end products RAGE: Receptor for advanced glycation end products RCS: Reactive carbonyl species ALEs: Advanced lipoxidation end products AR: Aldose reductase SDH: Sorbitol dehydrogenase PUFA-PLs: Polyunsaturated fatty acyl tail-involving phospholipids ROS: Reactive oxygen species PUFA-PL-OOHs: PUFA phospholipid hydroperoxides MDA: Malondialdehyde 4-HNE: 4-hydroxynonenal TCA cycle: The tricarboxylic acid cycle GAPDH: Glyceraldehyde-3-phosphate dehydrogenase GA-3-p: Glyceraldehyde-3-phosphate DHAP: Dihydroxyacetone phosphate MG: Methylglyoxal PKC: Protein kinase C GSH: Glutathione TLRs: Toll-like receptors PRRs: Pattern recognition receptors NADPH: Nicotinamide adenine dinucleotide phosphate NOXs: NADPH oxidases TGF-1: Transforming growth factor-1 TGFR1: TGF- receptor 1 TGFR2: TGF- receptor 2 Nrf2: Nuclear factor E2-related factor 2 KEAP1: Kelch-like ECH-associated protein 1 sMAF: Small musculoaponeurotic fibrosarcoma ARE: Antioxidant response element GSK3: Glycogen synthase kinase-3 GPX4: Glutathione peroxidase 4 References Abdelkader H, Mustafa WW, Alqahtani AM, Alsharani S, Al Fatease A, Alany RG

However, the clinical outcomes from ACI are not always efficacious or consistent

Biochem Biophys Res Commun 297: 10331042, 2002