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Advances in Tagging Systems That Preserve Native Protein Sequences In the case of conventional tags, an additional sequence is inevitably introduced at the linker region, which can interfere with accurate evaluation of the proteins function

Consequently, membrane integrity is lost, producing a detergent-like effect, which eventually disintegrates the membrane by forming micelles, followed by bacterial cell death (Qiu et al., 2020

This paper highlights the important molecular features of SOD1-ALS, which is not a TDP-43 proteinopathy and may partially explain why treatments evaluated in SOD1 -transgenic mouse models have not generally translated well to the clinic

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