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However, they were more than twice as likely to develop chronic lung disease (COPD) than nonusers

No concrete evidence of exactly what they smoked exists, but the most probable theory is that the tobacco was much stronger, consumed in extreme amounts, or was mixed with other, unknown psychoactive drugs

For heavy smokers who previously consumed over a pack of cigarettes a day, starting with a nicotine strength of 18 to 20 mg/ml is often recommended to tackle nicotine cravings and withdrawal symptoms, as this can provide a similar level of nicotine to what they were accustomed to