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34 ChenS.LiX.WuJ.LiJ.XiaoM.YangY.et al (2021)

Standard oral glutathione supplements often have very poor bioavailability

Nevertheless, reduction of intracellular heme levels resulted in a dramatic decrease of Ucp1 and OXPHOS mRNA and proteins ( Figure 1b and c ), indicating that thermogenic potential and mitochondrial function of brown adipocytes are tightly linked to intracellular heme homeostasis