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Specifically, Horvth and Vgh (2010) reported that when recombinant Hsp70 was added to cancer cells (Figure 5B [ a ]), it is transported via late endosome [ b ] into the acidic lysosome [ c ] by endocytosis, where it interacts with an anionic phospholipid, bis(monoacylglycero)phosphate (BMP)[ d ]

doi: 10.1016/j.biopha.2020.110036 100 TatematsuMTakahashiMFukushimaSHananouchiMShiraiT

Beyond upregulating antioxidants, silybin exerts direct protective effects on the mitochondria themselves, which is vital for patients battling the profound fatigue and PEM associated with ME/CFS