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Thus, the concentration of HGF in serum may be a potential predictive marker for sorafenib efficacy (Shao et al., 2015) and the combination of HGF and c-Met inhibitors and sorefenib could improve the efficacy of the first line systemic treatment (Goyal et al., 2013

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Blob picker was used for initial particle selection from 1210 out of a total of 1216 micrographs, followed by several rounds of 2D classification, resulting in the selection of 269,729 particles to generate a good initial model with obvious secondary structure features by ab initio reconstruction