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However, vast intra- and interfamilial variability tells a much wider clinical presentation [4,5,6] and an important overlap with other EDS subtypes and HCTDs [1, 9, 16, 28,29,30]

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The objectives of this study are: (a) to estimate, with categorical and nonparametric models, the risk of COPD in current smokers compared to never smokers, related to smoking duration, smoking intensity, lifetime tobacco consumption and age at smoking initiation and (b) to assess how the COPD risk is reduced with the increase of years of cessation