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FIGURE 1:Plasma Concentrations of Diazepam and Desmethyldiazepam Following Diazepam Rectal Gel or IV Diazepam Metabolism and Elimination:It has been reported in the literature that diazepam is extensively metabolized to one major active metabolite (desmethyldiazepam) and two minor active metabolites, 3-hydroxydiazepam (temazepam) and 3-hydroxy-N-diazepam (oxazepam) in plasma