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It tends to develop after years of HPA axis overdrive when the adrenal glands have been pushed to their limit and output begins to drop

Escribano BM, Colin-Gonzalez A, Santamaria A, Tunez I (2014) The role of melatonin in multiple sclerosis, Huntingtons disease and cerebral ischemia

Treatment of cells Hepatoma HepG2 cells were maintained in DMEM (GE Healthcare, Buckinghamshire, UK) supplemented with 10% fetal bovine serum (FBS), 100 U/ml penicillin and 100 g/ml streptomycin at 37 C in 5% CO 2