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It inhibits the activity of two key bacterial enzymes, DNA gyrase and topoisomerase IV, which are type II topoisomerases essential for DNA replication, transcription, repair, and recombination (Fish and Chow, 1997)

These tobacco smoking-respiratory findings were supported by multivariable MR analyses accounting for alcohol and cannabis use and abuse, which in addition to the broadly consistent IVW results (within the IVW MR 95% confidence interval but typically less precise) with estimates from the weighted median, weighted mode, and MR Egger sensitivity analyses strengthen causal inference