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There are notable differences in general disease characteristics such as the faster progression rate in EOAD with more frontotemporal atrophy rather than hippocampal atrophy in LOAD and primarily poorer executive, motor and visuospatial functions in comparison to the primarily poorer memory evident in LOAD (Tellechea et al., 2018)

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After that, we further performed propensity score matching (PSM) to match the age distribution and eventually resulted in a dataset with 1,290 scans of patients with AD and 1,290 scans of age-matched CN volunteers (Supplementary Figure S4b bottom left)