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The search was restricted to articles in the English language, studies performed on human subjects, but were not limited by study design

Schedule I classification: MDMA was placed on Schedule I by the DEA in 1985 after brief exploratory clinical use in the 1970s and early 1980s, which was pioneered by chemist Alexander Shulgin and documented in his 1991 collaboration PiHKAL

RU58841 belongs to the latter group: it is androgen receptor antagonist , designed to act locally, in the scalp, without the ambition of systemic blocking of androgens throughout the body

Because these products are designed to stay closer to skins natural pH, they often feel gentler