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It was found that some natural medicine extracts, proprietary Chinese medicines and Chinese herbal formulas reduce F/B ratio by decreasing Firmicutes abundance and increasing Bacteroidetes abundance, such as Guizhi Tang (GZT) (Yuan et al., 2021), Naoxintong Capsule (NXT) (Lu et al., 2022), Huanglian Jiedu Decoction (HLJD) (Miao et al., 2022), Danggui Shaoyao San (DGSY) (Yu et al., 2021), Laminaria japonica polysaccharide (LJP) (Zhang et al., 2021d), Porphyran-derived oligosaccharides (PYOs) (Wang X

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S., Mukherjee, T., Elmer, J

In lung cancer cells, EGLN1 and c-Myc are recruited to the promoter of lymphoid-specific helicase (LSH) at two hypoxia inducible factor-1 (HIF-1) binding sites, which directly facilitates the expression of LSH by inhibiting HIF-1[115]