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TNF- stimulates the production of IL-1 and IL-6, thereby reinforcing a positive feedback loop that sustains inflammation [47]

Al-Majed and colleagues [140] found that carnitine deficiency and oxidative stress are risk factors during development of cisplatin (CDDP)-induced cardiomyopathy and that carnitine supplementation, using propionyl-l-carnitine, prevents the progression of CDDP-induced cardiotoxicity

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