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F35E12.5 ( irg-5 ) was the most significantly up-regulated gene in the data set

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Heart valve disease include aortic valve insufficiency, aortic valve stenosis, hear murmurs, aortic valve prolapse, mitral valve prolapse, tricuspid valve prolapse, mitral valve insufficiency, mitral valve stenosis, pulmonary atresia, pulmonary valve insufficiency, pulmonary valve stenosis, tricuspid atresia, tricuspid valve insufficiency, and tricuspid valve stenosis

The claim that "over 75% of patients achieve significant pain relief without surgery" with peptide therapy comes from clinical observations, not controlled trials