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Crucially, the review delves into new gene expression data (e.g., from the Broad Institute's Connectivity Map), showing that GHK-Cu can significantly up- and down-regulate thousands of human genes, often reversing gene expression patterns associated with disease or aging

[DOI] [PMC free article] [PubMed] [Google Scholar] [12].Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, Mitch WE, Harrison DG, Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

f , TA cloning-based sequencing of H4 Q27A cells showing 51% of alleles carrying the Q27A mutation