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[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Pinto A., Bonucci A., Maggi E., Corsi M., Businaro R

FIGURE 4 3.1 Modulation of inflammatory signaling pathways 3.1.1 Inhibition of nuclear Factor- B (NF- B) pathway Glycyrrhizin exerts anti-inflammatory effects and directly protects hepatocytes by regulating genes such as interleukin-4 (IL-4), fibroblast growth factor 10 (FGF10), inhibiting Inhibitor of kappa B (I B) phosphorylation and p65 nuclear translocation to suppress NF- B activation in hepatocytes, thereby reducing the production of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) (Hsiang et al., 2015

DNA methylransferase inhibitor 5-azacytidine was one of the chemotherapeutic agents used to reactivate HbF but it was quickly abandoned due to its toxicity and carcinogenicity

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