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doi: 10.1074/jbc.M104746200 128 QiaoLLuoGG

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It also activates mitochondrial-mediated apoptosis through downregulation of anti-apoptotic proteins (Bcl-2, survivin) and upregulation of pro-apoptotic markers (Bax, Bid, cytochrome c, and caspases 3, 8, and 9) (Ren et al., 2015