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6-OHDA, a hydroxylated analogue of dopamine, is widely recognized for its ability to induce severe oxidative stress and dopaminergic neuronal damage both in vitro and in vivo, making it a commonly used agent for PD model induction (Masoudi et al

These extracts, known for their antioxidant and anti-inflammatory properties, were found to enhance glutathione levels and antioxidant enzyme activity, thereby mitigating free radical damage induced by 7,12-dimethylbenz[a]anthracene (DMBA) (57)

Other pathways implicated, explaining the development of vitiligo, include autophagy and ferroptosis, where oxidative stress impacts the cells ability to clear damaged components, eventually leading to cell death and depigmentation 17,46

2010;(11):CD008040