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Therefore, it would appear that the decrease in intranuclear NFkappaB and an increase in IL-10 may cause the inhibitory modulation on p47(phox) subunit and ROS generation by MNC following hydrocortisone and other glucocorticoids

Thus, further research is needed to uncover the dynamic biochemical and biophysical changes in the ECM during tumor progression, particularly those that lead to increased matrix stiffness, an essential factor in promoting various pro-tumor effects