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This prompted a randomized double-blind, crossover trial of amantadine, modafinil, and methylphenidate in MS

PloS One 6 (7), e21851

Treatments that don't produce the measurable lymphatic clearing and circumference reduction that indicate effective fat elimination leaving metabolic byproducts in the tissue

The mTORC1 inhibition by AMPK is accomplished by direct phosphorylation of the regulatory-associated protein of mTOR (Raptor) [264] and indirectly via activation of TSC2 [265, 266]