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Survival signaling monitored by IGFIR phosphorylation, levels of insulin receptor substrates 1 (IRS1) and 2 (IRS2) and Akt phosphorylation, was reduced in APAP-treated wild-type primary hepatocytes, but preserved in PTP1B / cells

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The activation was further enhanced by hydrogen peroxide

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Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence

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