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NF-B acts as an inflammatory switch that induces genome-wide epigenetic modification upon ultrafine PM exposure 26

By inhibiting NNMT, it leads to an increase in intracellular levels of NAD+ (nicotinamide adenine dinucleotide), a critical coenzyme for cellular metabolism and mitochondrial energy production

10.7 Novel metabolic interactions among neurons, astrocytes, and microglia 10.7.1 Neuron: metabolon at the synapse Beyond relying on global somatic energy production, emerging evidence suggests the existence of localized metabolons within neurons, particularly at presynaptic terminals (Li and Sheng, 2022)

The mechanism by which mitochondrial function regulates liver metabolism and therefore, interferes with the disease progression has been intensively investigated