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It is thought that 2-HG may serve as an oncometabolite by impairing cellular functioning via a variety of epigenetic and metabolic mechanisms ( 2-HG is known to interfere with glutaminergic signaling and the functioning of -KG dependent enzymes, including those that are central to the regulation of hypoxia-inducible factor 1-alpha (HIF1) and vascular endothelial growth factor (VEGF) ( The categorization of GBM into molecular subtypes has evolved over the years

MDA-protein adducts A largely coincident protein repertoire as the one delineated by anti-HNE antibodies was compiled by the immunochemical detection of N-MDA-lysine