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Future studies should investigate the functional consequences of increased CAR-SIV expression in human cells, specifically examining its role in promoting viral persistence and spread within the insulin secretory granules

H4K8la is enriched at promoters of meiotic genes and recombination hotspots, co-localizing with SPO11, DMC1, RAD51, and cohesin components (RAD21L, REC8), suggesting that lactylation serves as a metabolic cue coordinating gene activation and recombination during germ-cell meiosis [89]