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In addition, PHDs were shown to absolutely rely on the co-factors oxygen (O 2 ) and iron (Fe 2+ ), thus, identifying PHDs as cellular oxygen sensors [43]

We propose that the iron addiction of brain cancer cells provides a specific susceptibility, whereby removing their iron buffering mechanism via targeting of ferritin can result in favorable treatment outcomes, including the induction of iron-dependent cell death

By exploring zincs influence on each component of the immune system, from innate responses mediated by neutrophils and macrophages to adaptive immunity regulated by T and B lymphocytes, this review underlines the importance of zinc for immune health in aging populations

After 18 months, drusen size stable on fundus photos, no progression to larger/more numerous drusen that occurred in untreated sibling