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6 While the role of conventional cigarette smoking in oral cancer development is well-known, the role of ENDS in oral cancer and systemic disease is less clear

Macrophages regulate epithelial and stromal cell function by secreting enzymes and inflammatory factors that act directly and indirectly on airway structural cells, such as IL-1, TNF-, IL-8, monocyte chemoattractant protein-1(MCP-1), reactive oxygen species (ROS) and MMPs, directly involved in the process of airway remodelling 60,61

Although relatively new, HTP have been steadily increasing in popularity across the globe

It isn't a complete surprise that some young people are "going back to the product they were trying to quit in the first place," said Pamela Ling, a professor of medicine at the University of California-San Francisco who studies tobacco and its marketing