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Description

AURKB promotes colorectal cancer progression by triggering the phosphorylation of histone H3 at serine 10 to activate CCNE1 expression

Based on data coming from studies employing specific CYP isozyme substrates, it appeared that the rate of CYP1A2 and CYP2C19 drug-substrate metabolism decreases with age, whereas the CYP3A4-, CYP2A6-, CYP2C9- and CYP2D6-dependent substrate metabolism is slightly or not modified (102, 130, 131)