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The mechanisms proposed to explain the role of smoking in these disorders include mucosal damage, changes in gut irrigation, and impaired mucosal immune response

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Less common causes of nosebleeds Some less common causes of nosebleeds include: Atherosclerosis (build-up of plaque in arteries) Bleeding disorders (such as hemophilia or von Willebrand Disease) Exposure to irritating chemicals (such as cigarette smoke, sulfuric acid, ammonia and gasoline) Facial and nasal surgery Hereditary hemorrhagic telangiectasia (HHT) (a genetic disorder that occurs when blood vessels are malformed) High blood pressure Immune thrombocytopenia Leukemia Nasal cannula (a two-pronged medical device that delivers oxygen through the nose and can dry up nasal passages) Nasal infections Nasal tumors or polyps (growths in the nose or sinuses) Pregnancy Recreational drug use (such as cocaine or amphetamine) Sinus or pituitary surgery (also known as transsphenoidal) When to contact a health care provider about a nosebleed There are some situations when people should get in touch with a health care provider: Frequent or reoccurring nosebleeds Nosebleeds that arent caused by a cold or other minor irritations Nosebleeds that happen while someone is on blood thinners Nosebleeds that occur after sinus surgery or some other kind of surgery When to call 911 about a nosebleed In rare cases, a nosebleed may indicate a serious medical problem