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The onset time varies significantly by product type: vaping and cigarettes work fastest (5-10 seconds), nicotine pouches take 1-3 minutes, depending on the formula, while slower-release products like patches may take 20-30 minutes to begin working

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Clinically, affected individuals may develop liver cirrhosis, diabetes, cardiomyopathy, arthropathy and a bronze colour of the skin, which is responsible for the lay term 'bronze diabetes'

After reading this book, you might also want to visit the Ottoman History Podcast for a discussion on Plague in the Ottoman World, featuring Nkhet Varlk, Yaron Ayalon, Orhan Pamuk, Lori Jones, Valentina Pugliano, and Edna Bonhomme