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Mechanistically, it influences gene networks involved in tissue remodeling and exerts protective antioxidant and anti-inflammatory actions, partly through TGF- signaling and regulation of metalloproteinases

Many growth factors such as transforming growth factor (TGF)-, 2 platelet-derived growth factor (PDGF), 3 epidermal growth factor (EGF), 4 and fibroblast growth factor (FGF), 5 as well as interleukin (IL)-1 6 and tumor necrosis factor (TNF), 7 have been evaluated in a wide spectrum of in vivo and in vitro experiments to observe their effects on different elements included in the healing process

In the consensus CTG model, the sensitivity, specificity, and CCR were 78%, 74%, 76%, respectively for CPT-1 and 82%, 77%, 79%, respectively for CPT-2 (Figure 5)

Always use sunscreen, as both increase photosensitivity