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Taking into account available data concerning the alkylating nature of ethylene oxide, the demonstration of DNA adducts, and the overwhelmingly positive in vivo responses in mutagenic and clastogenic assays, the reproducible positive carcinogenic findings in animals, and the epidemiological findings suggesting an increase in the incidence of human cancer, ethylene oxide should be considered as a probable human carcinogen, and its levels in the environment should be kept as low as feasible

Shorted product amounts and perceived shrinkflation in cans

All nine countries covered by the report have been identified as both points of origin and destination for illicit cigarettes

Experimental units consisted of single 20-plant plots that were managed according to standard flue-cured production practices for North Carolina [33]