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Nie J, Shan D, Li S, Zhang S, Zi X, Xing F, et al

Principle of Accumulation When a drug is administered repeatedly at a fixed dosing interval () that is shorter than the time required for its complete elimination (approximately 4-5 half-lives), the drug will accumulate in the body

Hydrogen Sulfide can Scavenge Free Radicals to Improve Spinal Cord Injury by Inhibiting the p38MAPK/mTOR/NF-B Signaling Pathway

Newer strategies to address these drawbacks like combination therapy (use of structurally different chelating agents) or co-administration of antioxidants have been reported recently