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Environmental and lifestyle factors can accelerate these changes

This causal pathway relies on the fact that early rodent studies have unraveled the essential role for the DHT-AR signaling axis in preventing nipples from developing in male rats and mice, as well as the fact that available toxicity studies suggest strongest undervirilization effects (NR) with chemical substances that are either potent AR antagonists or prevent the synthesis of DHT

In this regard there is a notable interaction of A with ApoE and copper, as copper-A aggregation is enhanced with the addition of all ApoE isoforms, ApoE4 further enhancing copper accelerated A aggregation (Moir et al., 1999)

Br81-88