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While there were reported improvements in non-motor symptom scores for the 600 mg/day treatment group, no statistically significant changes in motor symptoms were observed when compared to placebo

96 MorrisD.KhurasanyM.NguyenT.KimJ.GuilfordF.MehtaR.et al (2013)

Among the several mechanisms proposed in attributing the ability of PPAR ligand in inhibiting leiomyoma cell growth, Houston suggested that the inhibition was mediated by negative cross-talk between ER and PPAR signaling pathway where the activation of PPAR inhibits ER-mediated gene expression (Houston et al., 2003)