dihexa nephrotoxicity kidney Cisplatin nephrotoxicity: new insights and therapeutic implications Conventional Chemotherapy Nephrotoxicity - Advances

Semax and NAD+ are not alternatives to each other, they are tools that address different levels of the same problem

doi: 10.1016/S0140-6736(23)01163-7

When beta-catenin accumulates in the nucleus of dermal papilla cells (the "command center" at the base of each follicle), it activates transcription factors (LEF-1, TCF-1, TCF-3, TCF-4) that upregulate genes like c-Myc and cyclin D1

Bmal1 knockout mice display lower blood pressure and abolished rhythmicity (Curtis et al., 2007), whereas Per1 has been implicated in aldosterone (Richards et al., 2013) and sodium regulation (Stow et al., 2012), both of which play a role in blood pressure maintenance