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Cytosolic SET protein and SET binding protein 1 (SETBP1) but not nuclear SET protein were increased in PBMC treated with alcohol and the drugs, which were correlated with increased expression of HIV-1 pol RNA or the luciferase reporter

If it impacts the testicular microenvironment, it could enhance sperm count or motility, but data are limited and the mechanism is different than how it might act in ovaries or endometrium