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Reward Pathways: GLP-1 RAs modulate the mesolimbic reward system (including the ventral tegmental area and nucleus accumbens), potentially reducing the hedonic drive to consume palatable foods and even moderating addictive behaviors (Zheng et al., 2024)

The reduced risk may be related to tobacco smoke compounds in glutathione S-transferase (GST) activity, which is involved in the nicotine detoxification pathway (Pachauri and Flora, 2013)