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Landry, Philip Morris marketing chief at the time, took notice

In contrast, in the DSS-induced colitis model, GPR15 activation enhances SMAD3/STAT5 signaling and promotes the differentiation of iTregs, thereby contributing to intestinal integrity

"Betel-quid and Areca-nut Chewing", Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines , International Agency for Research on Cancer, retrieved January 1, 2026 "Bidis: An Overview" (PDF)