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doi: 10.3389/fmed.2018.00061

[5] Toxicity, safety, and potential side effects [edit] General observations [edit] There is limited safety information available on the effects of kava consumption, but in general, moderate consumption appears unlikely to be harmful, while there is evidence of harm from heavy use

polygyrus -derived Hpb glutamate dehydrogenase (GDH), which reduced allergic airway inflammation in mice by inducing a switch from pro-inflammatory to anti-inflammatory eicosanoids (e.g., prostaglandins)

Therefore, the reduction in cortical BDNF delivery would result in diminished activity of the cortex and striatum synaptic activity and resulting in synaptic loss