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particularly oxidative and nitrosative stress pathways where it increases the oxidative burden, further triggers reactive nitrogen species (RNS, e.g., nitric oxide) and reactive oxygen species (ROS) effects of excitotoxicity and mitochondrial dysfunction

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While we dont yet know if the chemical vapor from e-cigarettes can cause hearing damage, or if e-cigarettes can compound or exacerbate a sensorineural hearing loss, the ototoxic properties of propylene glycol and other alcohol-based solvents have been studied in relation to eardrops and other products

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