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This dual mechanism produces synergistic metabolic effects, including enhanced insulin sensitivity and modulation of adipose-tissue function, ultimately resulting in greater weight reduction compared with GLP-1 RA monotherapy

This investigation revealed that membranes, cytoplasmic structures, and nuclear proteins typically denatured in temperatures of 40-70 , while the chromatin denatured at more distinct points, including: 60, 76, 88, and 105

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