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L2-Cmu does not perturb glucose homeostasis in older mice We then evaluated effects of chronic IGF-1R mAb treatment on energy and glucose homeostasis in an initial cohort of older mice

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Interestingly, some researchers have suggested that this dysfunction is not caused by UV irradiation but rather by cadherin-11 (CDH11), which leads to the destruction of the basement membrane through MMPs and subsequently causes hyperpigmentation