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At the molecular level, copper directly interacts with A and tau proteins, facilitating their abnormal aggregation, enhancing neurotoxicity, and promoting both A deposition and tau hyperphosphorylation, ultimately leading to neuronal dysfunction and injury (185)

Indeed, combination of natural selective HDAC inhibitors might increase the anticancer drug efficacy as demonstrated in the case of the natural HDAC6-selective inhibitor aceroside VIII (Ryu et al., 2015)

IFN- 1b plus atorvastatin has been shown in some studies to significantly lower high-sensitivity C-reactive protein levels in patients, indicating an anti-inflammatory effect of atorvastatin in MS (281)

Iron infusion therapy is especially suitable for patients who cannot tolerate iron supplements, do not absorb iron correctly in the gastrointestinal tract, or have chronic blood loss