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10.1536/ihj.21-76435569968 177 Chen C, Dong J, Lv Q, et al

Additionally, the overall quality of evidence for each outcome was evaluated using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) framework (Guyatt et al., 2008) which considers factors such as risk of bias, inconsistency, indirectness, imprecision, and publication bias to provide a comprehensive evaluation of the strength of evidence