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In addition to GSH, cysteine metabolism produces reactive sulfur species such as hydrogen polysulfides (H 2 S n ), which can act as nucleophilic and redox-active metabolites scavenging reactive oxygen species and lipid peroxyl radicals, thereby mitigating lipid peroxidation independently of the GPX4GSH axis [77,78]

Studies suggest that naringin, a natural compound found in citrus fruits such as grapefruit, may protect the liver from alcohol-related damage by reducing fat buildup, oxidative stress, and cell damage

Neurotransmitter Regulation: NAC assists in the regulation of glutamate, a neurotransmitter responsible for transmitting signals between the brain and nerves

[,] The liver and extrahepatic tissues or organs form a single line or multi-dimensional connection, which is directly based on anatomy, or mediated by the neuro-humoral factors, or caused by the pathogenic factors and others, thus forming a complex pan-liver network that is crucial for maintaining homeostasis and pathogenesis of disease