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Photosynth Res 116(23):455464

However, skin laxity is associated with poor support of the epidermis by the underlying dermis

4 Discussion Over the past decade, the use of PBPK modeling has been rising, and regulatory agencies have issued DDI guidance highlighting the use of such modeling approaches ( Firstly, it allows for the extrapolation of PK behavior of drugs in healthy volunteers to diseased or special populations (e.g., the elderly, children, pregnant women, and patients with hepatic and renal insufficiency)