Artesunate inhibited the Notch signaling pathway, decreased Jagged1, NICD, and Hes-1 protein expression, reduced TGF-induced -smooth muscle actin (-SMA) and collagen content in fibroblasts, and inhibited the differentiation of fibroblasts into myofibroblasts (Liu et al., 2017)
Disclosures: Anna Goebel: Nothing to Disclose, Emily Sheng: Nothing to Disclose, Pedro Ochoa-Allemant: Nothing to Disclose, Nadim Mahmud: Nothing to Disclose 933 RACIAL AND ETHNIC DISPARITIES IN LIVER CANCER RISK BY BIRTH COHORT: AN ELECTRONIC HEALTH RECORD (EHR)-BASED EPIDEMIOLOGIC COHORT STUDY Chanda Ho 1 Janet Chu 2 Aly Cortella 2 Alison Canchola 2 Pushkar Inamdar 2 Pragati Kenkare 3 Jane Vu 3 Sixiang Nie 4 Ma Somsouk 5 Michele Tana 5 Caroline Thompson 6 Scarlett Gomez 2 Hashem El-Serag 7 Miok Kim 2 Mark Segal 2 Yihe Daida 4 Su-Ying Liang 3 Mindy Hebert-Derouen 2 Salma Shariff-Marco 2 , 1 Singapore General Hospital, 2 University of California San Francisco, 3 Sutter Health, 4 Kaiser Permanente Hawaii, 5 San Francisco General Hospital, 6 University of North Carolina, 7 Baylor College of Medicine Background: Hepatocellular carcinoma (HCC) is the sixth leading cause of cancer-related death in the United States
observed that noradrenaline or isoproterenol (epinephrine analog) induces cAMP accumulation, which is further driven by PKC activity
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