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The review situates Dihexa within the renin-angiotensin systems central nervous system arm, summarizes the HGF/c-Met activation hypothesis, and surveys behavioral pharmacology in rodent cognitive models

It is also banned by WADA (the World Anti-Doping Agency) for professional athletes

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In addition to regulation of blood glucose, insulin also modulates synaptic plasticity, cognition and aging-related neurodegeneration (Zhao and Townsend, 2009)